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Are you realizing the full value of your pharmacy partnership?

A pharmicist consults a CVS Pharmacy patient

How CVS Pharmacy can help payers manage costs, improve quality and support better member health

Health care payers invest significant resources in formularies, benefit designs, utilization management and clinical programs intended to control costs and improve member health. Realizing the full value of those strategies depends on consistent execution at the moments when members make medication and health care decisions.

A few core moments can materially shape value across a covered population: starting and staying on an appropriate therapy; choosing a clinically appropriate, lower-cost alternative when available; identifying medication or other health risks before they contribute to emergency department visits or hospitalizations; and receiving recommended vaccinations before preventable illness leads to more costly care.

Individually and collectively, these can have a significant effect on pharmacy spend, medical utilization, quality performance and member health outcomes.

Payers already use benefit design, provider engagement and member outreach to encourage clinically appropriate, cost-effective care. An effective pharmacy partner can meaningfully reinforce these efforts at consequential points in the member journey: when a prescription is started, refilled or changed and when a member has questions about their health or faces barriers to treatment.

Each interaction creates an opportunity to translate payer strategy into action by supporting adherence, closing care gaps, encouraging clinically appropriate lower-cost alternatives and identifying medication risks. Pharmacists provide an accessible, ongoing touchpoint, while effective digital tools and patient-targeted outreach can extend support between visits and can help address barriers across different member populations and markets.

CVS Pharmacy® brings together market-leading patient access, millions of daily interactions, local pharmacist engagement, extensive digital tool and analytics support and dedicated clinical programs to help payers activate strategies consistently at scale. These capabilities also generate pharmacy and engagement insights that can help identify intervention opportunities, target member support and measure program performance.

Three ways pharmacy patient engagement can help create system-wide savings

At a glance, pharmacy engagement can create value in three ways: helping members stay on therapy, supporting lower-cost medication choices and identifying medication risks before they become more costly events.

1. Reaching members before an adherence gap becomes a health risk

For individuals managing chronic conditions, missing or discontinuing medication can affect both health outcomes and health care costs. The challenge for payers is identifying members at risk and reaching them with relevant support before a gap in therapy leads to a more serious health event.

CVS Pharmacy uses proprietary patient data and targeted engagement capabilities to support members who may be at risk of falling off therapy. CVS pharmacist and technician outreach through dedicated Centers of Excellence, personalized digital messaging, and local pharmacy team engagement help connect members with refill and adherence support when it is most relevant to impact behavior or help address issues that may be negatively impacting adherence.

For payers, this type of stronger adherence can help improve chronic-condition management and medication-related quality measures while decreasing costly downstream healthcare events. Recent peer-reviewed evidence across many different chronic-disease populations associates better adherence with fewer emergency department visits, hospitalizations and lower medical costs. 

For example, a 2024 American Heart Association study showed adherence >80% PDC to antihypertensive medication among commercially insured 18-64 year olds was associated with $1,441 lower total medical cost per year, 200 fewer emergency department visits per 1,000 patients, and 89.6 fewer inpatient admissions per 1,000 patients*. A pharmacy partner with effective adherence support at scale and across conditions and member types can be a key component of helping patients and payers realize these types of benefits. 

2. Helping members use lower-cost alternatives when available

Formularies and benefit designs can establish preferred therapies, but their financial value depends on whether clinically appropriate lower-cost options are consistently used.

Generic medications can provide clinically appropriate, more cost-effective alternatives to branded drugs, helping members and payers manage prescription costs.

CVS Pharmacy also supports formulary adoption through patient and provider outreach that helps inform them about potential clinically appropriate alternatives. In one formulary optimization program, outreach earned a 96% patient satisfaction rating; in another, a health plan achieved a 4-percentage-point lift in formulary compliance and $1,992 in average annual gross plan savings per targeted, updated prescription.*

Applied across a large patient population, consistent use of lower-cost and preferred alternatives can help payers strengthen formulary performance and reduce unnecessary pharmacy spend at the point of dispensing.

3. Identifying medication risks before they become costly events

Medication-related issues can create both clinical risk and avoidable cost. Potential interactions, duplicate therapies, inappropriate dosing and complex medication regimens may go unaddressed until they contribute to a more serious health event.

CVS Pharmacy uses technology-enabled drug utilization reviews (Smart DUR) and specially trained pharmacist-led clinical programs to proactively screen patient’s prescriptions and identify opportunities for intervention.

CVS Pharmacy also conducts Comprehensive Medication Reviews on behalf of payers – leveraging the CVS #1 healthcare brand reputation among consumers* and geographically distributed local pharmacist outreach - to help uncover potential medication-related problems, improve members’ understanding of their therapies and identify opportunities to make medication use safer and more effective.

Identifying and addressing these concerns before complications arise can help payers support safer patient medication use and potentially avoid unnecessary downstream utilization.

A pharmacist provides a prescription consultation with two patients

Extending pharmacy engagement beyond the prescription

The financial impact of pharmacy engagement can extend well beyond the prescription itself.

When members receive appropriate medications, remain engaged in therapy and avoid disruptions in treatment, payers may see benefits across the health care system. Better medication use and clinical support can support improved management of chronic conditions, stronger quality performance and reduced total cost of care.

Exploring the potential impact on emergency department utilization

Emergency department utilization is an important driver of medical spend. In an observational analysis of members of a large national health plan who filled three or more retail prescriptions, members using CVS Pharmacy had approximately 6% fewer emergency room visits than members using competitor pharmacies and approximately 12% fewer visits than members using multiple pharmacies.* Note: findings showed a statistically significant association within the analyzed population, but do not establish that pharmacy choice alone caused the difference.

To illustrate the related scale of potential cost management impact, applying a separate benchmark of approximately 193 emergency department visits per 1,000 members to a hypothetical plan covering 10 million lives yields roughly 1.9 million annual visits. Applying the analysis’s upper-bound 12% association and an estimated average payer cost of approximately $3,250 per visit would equate to about 232,000 fewer visits and more than $750 million in potential avoided medical costs.*

The example underscores why pharmacy support should be evaluated beyond the pharmacy claim while keeping actual program results distinct from observational findings and modeled scenarios. The broader opportunity is to use timely pharmacy engagement to support better medication use and help address avoidable utilization and total cost of care.

Preventing costly illness through immunization

Pharmacy engagement can also create value by helping members receive recommended preventive care before illness results in more complex or costly treatment.

CVS Pharmacy provides payers with a scalable channel for immunization outreach, education, scheduling and administration. Its broad community presence and digital plus education engagement help make vaccinations easier for members to access,  while supporting payer efforts to close preventive care gaps.

 

Supporting quality performance and plan value

The value of pharmacy engagement is not limited to direct cost avoidance. Pharmacist-led refill outreach, medication counseling, immunization support and medication reviews can also contribute to measures that affect quality performance.

According to a Pharmacy Quality Solutions analysis, CVS Pharmacy ranked #1 in Medicare medication adherence performance for total member support across hypertension, cholesterol and diabetes measures.*

For Medicare plan sponsors, these measures can contribute to overall Star Ratings and support performance tied to quality bonus eligibility, plan competitiveness and broader business objectives. CVS Pharmacy adherence solutions have helped a major national health plan achieve higher Medicare Star performance through positive influence on adherence measures for hypertension, cholesterol and diabetes.*

The result is value that reaches across multiple payer priorities: better member support, stronger quality performance and improved financial outcomes.

Realizing more value through closer pharmacy partnership

Contract economics are one component of pharmacy cost management. The broader opportunity is to use pharmacy engagement to translate payer strategies into action and create value across pharmacy and medical spend.

When payers collaborate closely with pharmacy partners, they create more opportunities to support adherence, encourage cost-effective medication use, close preventive care gaps and address health risks before they lead to more costly care.

CVS Pharmacy combines broad community access, millions of patient interactions, digital tools, targeted outreach and pharmacist-led clinical programs to help payers execute consistently across populations and markets. Integrated pharmacy and engagement data can further help identify intervention opportunities and measure program effectiveness, subject to applicable data availability, permissions and program design.

The right pharmacy partnership does more than fill prescriptions or communicate benefits. It gives payers a scalable way to activate strategy at the point of care, engage members through accessible pharmacists and digital channels, and evaluate measurable results across pharmacy quality, medical utilization and member health.


What could greater pharmacy value mean for your population?

Connect with CVS Pharmacy to explore how targeted member engagement, pharmacist-led clinical support and population-level interventions can help advance your cost-management, quality and member health objectives.

Connect with CVS Pharmacy

 

  • *FOR 73% OF ENROLLED HIGH-RISK MEMBERS ACHIEVING OPTIMAL ADHERENCE: CVS Health Enterprise Analytics, based on a large national health plan’s 2024 program. Reflects members achieving adherence (PDC ≥80%) following interventions targeting Medicare Part D measures of hypertension, cholesterol and diabetes.

  • *FOR $1,441 LOWER TOTAL MEDICAL COST PER YEAR AND REDUCED ACUTE EVENTS: Lee, Jun Soo et al. Antihypertensive Medication Adherence and Medical Costs, Health Care Use, and Labor Productivity Among People With Hypertension. Journal of American Heart Assoc. 2024 Nov 5; Available at: https://pubmed.ncbi.nlm.nih.gov/39494551/

  • *FOR GENERIC SUBSTITUTION RATE ABOVE 98%: CVS Health Enterprise Analytics, 2026. Generic Substitution Rate (GSR) reflects prescriptions dispensed as generic when a generic alternative is available.  

  • * FOR 96% PATIENT SATISFACTION WITH FORMULARY-RELATED OUTREACH: Results from a Formulary Optimization campaign for a large national PBM, 2025. Satisfaction was ranked on a scale of 1–5 stars, with 96% representing an average of 4.8 stars.

  • * FOR 4-PERCENTAGE-POINT LIFT IN FORMULARY COMPLIANCE: Results from a Formulary Optimization campaign for a large national health plan, 2025.

  • * FOR $1,992 IN AVERAGE ANNUAL GROSS PLAN SAVINGS PER TARGETED, UPDATED PRESCRIPTION: CVS Pharmacy Analytics. Results from a Q2 2024 Formulary Optimization program targeting 2,000 Medicare members. Average annual gross plan savings were based on prescriptions filled by members included in the campaign between May and October 2024. Results may vary based on drugs targeted, plan economics, enrolled population demographics, member risk profiles and other factors.

  • * FOR CVS #1 HEALTHCARE BRAND REPUTATION: Morning Consult Study, May 2025. Available at https://morningconsult.com/reports/most-trusted-brands-2025

  • * FOR MORE THAN $1,300 PMPY SAVINGS AND HIGHER CARDIAC PDC: CVS Health Analytics; n=6,685. Comprehensive Medication Reviews completed January 1–September 1, 2024. Data reflects 12-month post-period outcomes; cardiac PDC levels in the post-period were compared with a control group of patients whose pre-period PDC was below 0.8.

  • * FOR APPROXIMATELY 6% AND 12% FEWER ER VISITS: Large national health plan observational analysis, 2024. Among members filling three or more retail prescriptions annually, CVS Pharmacy users had approximately 6% fewer emergency room visits than competitor-pharmacy users and approximately 12% fewer visits than members using multiple pharmacies. The analysis identifies an association and does not establish exclusive causation; results may not generalize to other populations.

  • * FOR APPROXIMATELY 193 EMERGENCY DEPARTMENT VISITS PER 1,000 MEMBERS AND THE ILLUSTRATIVE 10-MILLION-LIFE SCENARIO: Aetna Informatics, Emergency Room and CVS MinuteClinic Cost and Utilization report, May 1, 2025–April 30, 2026, reports 192.8 emergency room visits per 1,000 members for the analyzed commercial population; rounded to 193 for illustration. Applying that benchmark to a hypothetical 10-million-life population, then applying the separate 12% observational association and an estimated $3,250 average payer cost per visit, yields approximately 232,000 fewer visits and more than $750 million in potential avoided costs. This is a modeled illustration, not an actual program result, forecast or guarantee. Actual utilization and savings vary by population, methodology, benefit design, geography, intervention and other factors.

  • * FOR UP TO $27B IN ANNUAL VACCINE-PREVENTABLE DISEASE BURDEN: Estimated economic burden of adult vaccine-preventable diseases in the United States ranges from approximately $9 billion to $27 billion annually, depending on pathogens included and cost categories evaluated. Sources include Ozawa et al., Health Affairs (2016), McLaughlin et al. (2015), and subsequent health economics modeling.

  • * FOR #1 RETAIL IMMUNIZER IN THE U.S.: Based on 2025 IQVIA data. Available at iqvia.com.

  • * FOR #1 MEDICARE MEDICATION ADHERENCE PERFORMANCE: Pharmacy Quality Solutions (PQS), 2025. CVS Rx patient Proportion of Days Covered (PDC) medication target attainment for hypertension, cholesterol and diabetes conditions. Calculated based on contracted support to improve adherence for the full member population of two national health plans.

  • * FOR HIGHER MEDICARE STAR PERFORMANCE: CVS Pharmacy case study, 2024. CVS Pharmacy support positively influenced Medicare Part D adherence measures for hypertension, cholesterol and diabetes, supporting attainment of a higher adherence measure cut-point level for a large national health plan.